Orchard Therapeutics

Scientist (Cell & Gene Therapy Technologies)

BiotechMid
Orchard Therapeutics
's Mission

Dedicated to transforming the lives of patients with inherited diseases through innovative gene therapy.

What you'll be doing

  • Developing stable cell lines for LVVs;
  • Designing, developing and improving process(es) (USP and DSP) for LVVs to deliver robust manufacturing platforms for early and late-stage clinical and commercial development;
  • Developing and performing cell-based and biochemical assays to characterise LVV processes and products;
  • Executing experimental plans, analyse and interpret experimental data, maintaining experimental results in relevant databases and writing technical reports;
  • Providing hands-on technical expertise/scientific guidance to team members and supervision of junior colleagues;
  • Contributing to the routine lab maintenance;
  • Contributing to the transfer of stable cell lines and improved processes to GMP and assist with oversight of manufacturing activities as required;

Requirements

  • In-depth knowledge on the state-of-the-art of cell & gene therapy products and available technology, more specifically regarding viral vectors;
  • PhD+3 years (academic/industrial) or additional industrial experience with development, manufacture and delivery of viral vectors, preferably retro and lentiviral vectors;
  • Demonstrated skills and hands-on experience in tissue culture techniques and handling of adherent and suspension cell lines in different culture systems;
  • Demonstrated skills and hands-on experience in molecular biology and vectorology, including cloning, standard DNA and RNA technology, analyses with qPCR, recombinant protein expression and assessments with SDS-PAGE, Western blot, ELISA, flow cytometry and others;
  • Demonstrated knowledge and hands-on experience with stable cell lines development for retro and lentiviral vectors;
  • Demonstrated knowledge in designing and developing processes for LVV production and purification;
  • Experience in developing and performing analytical methods for stable cell lines and LVV characterization;
  • Use of more specialist lab equipment e.g. flow cytometers, cell counters, cell sorters, microscopes and imaging systems etc
  • Ability to work collaboratively as part of a multi-disciplinary team, or independently as necessary;
  • A minimum PhD or equivalent in biotechnology, process development, cell line development, cell and gene therapy, biological sciences, or other relevant scientific discipline.

Company Values

Company Benefits

  • Work from home opportunities
  • Health insurance
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