Orchard Therapeutics

Scientist, Analytical Development - Cell Based Assays

BiotechMid
Orchard Therapeutics
's Mission

Dedicated to transforming the lives of patients with inherited diseases through innovative gene therapy.

What you'll be doing

  • Working in the laboratory to develop and/or re-optimize new and existing analytical methods for the lot release and characterization of HSC-derived gene therapy products with specific cell-based potency assay development expertise.
  • Routine operation of potency assays and other analytical methods to support characterisation of HSC-derived gene therapy products as required.
  • Overseeing analytical method development and optimization with external partners as required.
  • Execution, review and approval of method development reports, protocols and process documents as required.
  • Assisting in the preparation of CMC regulatory submissions.
  • Assisting with comparability protocol design and execution as required

Requirements

  • Minimum of three years of experience in the biotechnology or pharma industry with a primary focus on the development of analytical methods for product development, characterization and lot release testing.
  • Demonstratable experience of development and optimization of cell-based assays (e.g. FACS, HTRF, ELISA, Luminescence, etc) for lot release and characterization.
  • Demonstratable experience of engineering cell lines to include (e.g.) vector construction, exogeneous expression of cell surface receptor(s), single cell cloning, etc,
  • Demonstratable experience of characterization and maintenance of transfected, clonal and primary cell lines.
  • Knowledge of analytical method qualification and validation.
  • Experience with the development and application of analytical techniques, including Capillary Electrophoresis, DNA sequencing, qPCR/PCR, ddPCR.
  • Experience of the characterization and lot release testing of viral vector-based and/or cell-based products desirable.
  • Sound understanding and demonstrated application of statistical methods/tools.
  • Ability to operate in a fast-paced, multi-disciplinary industrial environment
  • PhD in Biological Sciences, Bioengineering, Chemistry or an associated discipline or Masters of Science

Company Values

Company Benefits

  • Work from home opportunities
  • Health insurance
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