GammaDelta Therapeutics

Principal Scientist Discovery

BiotechExpert
GammaDelta Therapeutics
's Mission

Our mission is to deliver highly effective allogeneic immunotherapies based on the unique properties of Vδ1+ T cells with potential to provide additional benefits towards patient survival in the treatment of cancers. Our proprietary isolation and expansion protocols have the ability to selectively generate Vδ1+ T cell populations suitable for clinical application.

What you'll be doing

  • Design, plan and lead research-orientated immunological activities related to the biology and engineering of γδ T cells and unconventional lymphocytes in order to support GDT’s pipeline discovery and development of anti-cancer T cell therapies including gene engineered approaches.
  • Line management and development of a small team responsible for:
  • Studying and describing the biology of γδ T cells and other unconventional innate lymphocytes.
  • Process discovery and gene engineering PoC studies for novel early stage platform candidates.
  • Design and implementation of a PD and CMC enabling data package including descriptive biological quality attributes to enable hand over of early candidates to process development
  • Create discovery data to enable and ultimately support the filing of novel intellectual property.
  • Work closely and support R&D colleagues responsible for gene engineering and vector production to enable gene engineering discovery research and process discovery as well as process development of gene engineered pipeline candidates.

Requirements

  • Educated to PhD level with at least 5 years experience, preferably in Biotech
  • Prior working experience with unconventional lymphocytes, ideally γδ T cells
  • Existing initial industry experience in the field of gene engineering pf lymphocytes
  • Extensive practical expertise, including techniques such as primary T cell culture, gene engineering and cloning, real-time quantitative PCR, vector production, cell-based functional assays and immune assays, including multiparameter flow cytometry
  • Flexible, pragmatic and practical, highly motivated to ensure that studies meet challenging timelines and able to propose practical, compromise solutions to problems
  • Ability to work independently, take the initiative, planning and managing multiple and varied tasks and prioritize workload
  • Commitment to high-quality research standards, with attention to detail and rigorous record keeping and data integrity
  • Ability to work co-operatively with others, as part of a team, engaging constructively with colleagues at all levels to deliver objectives, using effective scientific communication skills
  • Enjoys working in a structured environment and able to comply with the Company’s Standard Operating Procedures and Policies
  • Good IT skills including confidence with use of scientific software

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